Mouse C1 Inhibitor Genetically Deficient Lung Tissue Lysate from Innovative Research is prepared from a C1 Inhibitor Homozygous Knockout Mouse. This C1 Inhibitor Homozygous Knockout was created by targeted excision of the SERPING1 gene. Homozygous mice completely lack C1 Inhibitor protein expression. Organ is flash-frozen immediately upon removal and stored frozen until lysed. The tissue is then lyophilized and thorougly homogenized in Radio Immuno Precipitation Assay (RIPA) buffer containing protease and phosphate incubators. The final homogenate is then incubated with DNase, clarified via centrifugation (10,000g at 4░C) and stored at -80░C. Each lot is tested for protein concentration via BCA assay and analyzed via SDS-PAGE to confirm the presence of sharp, clear bands as an indicator of quality. Product Details: Species:Mouse Antigen:C1 Inhibitor Format:Tissue Lysate Storage Conditions:-70 C This product can be useful as a control in a wide range of in vitro applications, including ELISA and Western Blot, among others. Useful for research in areas like hemorrhagic shock, septic shock, transplant rejection, reperfusion injury, inflammatory disorders, and hereditary angioedema. Mouse Model Details Strain:C57BL6/SJL Chromosome:2 Gene:SERPING1 Genomic TargetIntron 1, Exon 8 Mutation:9244 base pair deletion Phenotype:Absence of C1 Inhibitor protein expression and increased vascular permeability At Innovative Research, we provide reliable, consistent products that deliver reliable, consistent results.