Mouse CD152 [CTLA-4] Recombinant Protein Fc Tag Lyophilized from Innovative Research has been recombinantly produced in NS1 cells. This is a Lyophilized protein buffered in Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 1mg/ml in sterile water. Add 1X PBS to the desired protein concentration. with a purity of >98% (SDS-PAGE). Endotoxin level is less than 0.06EU/ and#956;g protein (LAL test; Lonza)..More Details: Species: Mouse Target: Ctla4 Purity: >98% (SDS-PAGE). Endotoxin level is less than 0.06EU/ and#956;g protein (LAL test; Lonza). Source: NS1 cells Storage Conditions: Stable for at least 1 year after receipt when stored at -20░C. Working aliquots are stable for up to 3 months when stored at -20░C. Additional Information:CD152 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4 and CD8 T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4 T cells and 50% of CD8 T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.This recombinant proteins is for research use only.. At Innovative Research we provide reliable, consistent products that deliver reliable, consistent results.